Isothermal Titration Calorimetry

Isothermal Titration Calorimetry requires the highest level of calorimetric sensitivity and stability, efficient titrant delivery, and a user-friendly platform which facilitates easy cleanup and rapid turnaround. Employing unique and proprietary technology, the TAM III is the ideal system for Isothermal Titration Calorimetry and excels in the most demanding ITC applications such as ligand binding.


The TAM Isothermal Titration Calorimetry (TAM-ITC) system consists of a nanocalorimeter, 1 ml removable titration ampoule with stirring facilities, and a precision syringe pump for efficient titrant delivery. The TA Instruments nanocalorimeter is the most sensitive calorimeter available for the TAM III, and can readily detect microjoule level heat flow. In power compensation mode, the response time of the calorimeter is optimized, and the temperature of the sample is held virtually isothermal. This is a major benefit over competitive designs, in which the sample temperature is allowed to drift during titration.