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Simultaneous DSC - Raman Analysis of a Pharmaceutical Polymorph

Many drugs are formulated as solids. Although convenient and compact, solid drug formulations can be problematic because potentially the active pharmaceutical ingredient can exist in more than one thermodynamically or kinetically stable crystalline or amorphous form, and can interconvert between these forms during processing or storage. The ability of a compound to exist in different solid state crystalline forms (polymorphism) impacts the solubility, and thus the bioavailability, of the pharmaceutical.

In this paper, we describe a simultaneous DSC-Raman analysis of a pharmaceutical polymorph, carbamazepine. By performing the simultaneous analysis, the complementary DSC and Raman data can be correlated and a more complete characterization of the material is accomplished.

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